About

Cyrille Botté is a CNRS Research Director who leads the CNRS-INSERM Apicolipid research team at the Institut for Advanced Biosciences in Grenoble (Twitter: @ApicoLipid). His team focuses on understanding how Apicomplexan parasites (intracellular human pathogens responsible for major human diseases including malaria and toxoplasmosis) acquire lipids and nutrient essential for their propagation, survival, and pathogenesis within their human host. He obtained his PhD in 2007 at the Université Grenoble Alpes, and then coordinated a FP7 Marie Curie Actions project (2008-2011) between the University of Melbourne (Australia) and the Université Grenoble Alpes. He joined the CNRS in 2013 and set up an ATIP-Avenir-Finovi research team “Lipid synthesis and membrane biogenesis in malaria and toxoplasmosis” at the Institute for Advanced Biosciences (CNRS UMR5309 INSERM U1209 Université Grenoble Alpes). His team developed a strong expertise in parasite lipid analysis, lipidomic and fluxomic analysis, and set up major facilities and equipment in their premises, such as a P3* cell culture facility (HCB #3573), and a fully independent lipidomic-fluxomic platform (both part of a larger core facilities (http://gemeli-uga.fr/GEMELI.html). They have thus extended a larger metabolomic-lipidomic platform dedicated to health, which activity spans to infections, cancer, metabolic signature, cohorts… His team is part of the national labex Parafrap (https://labex-parafrap.fr/en/labex-parafrap), and recently a Fondation pour la Recherche Médicale Team 2021. His team currently focuses on the metabolic pathways allowing membrane biogenesis, lipid synthesis/trafficking/signalling, host-parasite metabolic interactions, and sensing/adaptation of pathogens to host nutritional environment.

Team info

Team name:
Affiliated team: Yes
Website: http://
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Scientific info

Research domains pathogènes/parasites
trafic intracellulaire
lipid synthesis, trafficking, signalling
metabolism
membrane biogenesis
host-pathogen interactions
metabolomics/lipidomics
Organelle/Compartment chloroplastes
endosomes/lysosomes
enveloppe nucléaire
membrane plasmique
mitochondrie
noyau
réticulum
Techniques imagerie confocale
imagerie frap, flim, fret, etc
microscopie electronique
metabolomics-lipidomics
Cell Models lignees cellulaires
Plasmodium falciparum
Toxoplasma gondii