Institute for Advanced Biosciences Grenoble, France –

DEAD LINE coming soon : 30th June 2022

Define, organize, animate and promote an original research project within IAB
scientific strategy, matching its keywords “epigeneticsenvironmentcellular
plasticitycancer” as described below;

Implement the project to produce, use and disseminate knowledge in compliance
with Inserm missions and values based on responsible research conduct and ethical
and regulatory requirements. strategy

Contribute to academic education in the areas covered by the project

Priority research themes
1. Strategy of the Institute for the Advancement of Biosciences (IAB)

IAB develops fundamental and translational research programs with a focus on
understanding the molecular and cellular mechanisms by which organisms develop and adapt to the constraints of their environment at all scales of the living (from the molecule to the ecosystems). This strategy is based on 4 keywords: epigenetics, environment, cell plasticity and cancer. IAB brings together 18 teams and research groups supported by 6
platforms and technical platforms (300 staff). Located on the health campus in Grenoble (next to University hospital CHUGA) , IAB is positioned as a link between the fundamental and mechanistic research potential of the site and application to health, through a strong translational and valorization strategy. The main points of application in health are cancers, infectious diseases (viruses and parasites), pathologies of infertility and prevention of environmental exposures in early life. IAB develops a rich network of close collaboration with research centers of the Grenoble site, in particular EMBL, IBS and UGA molecular chemistry and physics departments.

2. Priority themes

The project will aim to develop original approaches to study the interactions between the dynamics of the epigenome, cellular metabolism and the cellular and mechanical microenvironment. The project will aim to contribute to a better understanding of the processes that control cellular plasticity and their deregulation during pathologies such as cancer. In addition to a solid fundamental component, the project must offer a translational
dimension (discovery of biomarkers, new therapeutic targets, experimental therapies).
Two important criteria are (1) originality and relevance of experimental models and effective capacity to implement them; (2) consistency of the project with the strategic themes carried by the departments and teams of the IAB.

Contacts for further information

Pierre Hainaut, Director of IAB :

Corinne Albiges-Rizo, head of department IAB:

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