About

The team entitled “Membrane Dynamics of Host Parasite Interactions” has been created under the lead of I. Tardieux for the 2016-2020 HCERES-INSERM contract at the Institute for Advanced Biosciences/IAB (INSERM U1209, CNRS UMR 5309, Univ. Grenoble Alpes/UGA). Moving from the Institute Cochin (Paris), IT team continues to develop quantitative high-speed live and high-resolution static imaging to identify and characterize key early processes governing Toxoplasma parasite-host cell interactions while mostly focusing on Toxoplasma motile and invasive skills. The team has now been renewed for the 2021_2016 contract by the HCERES-INSERM- CNRS and UGA, and re-entitled “Biomechanics of Host Parasite Interactions. The research it develops is optimally integrated in a collaborative local network made of (i) physicists from the LIPhy (Laboratory of Interdisciplinary Physics), nanochemists (Department of Molecular Chemistry) (ii) parasitologists and cell mechanobiologists from IAB.

Team info

Team name: Biomechanics of Host-Parasite Interactions
Affiliated team: Yes
Website: https://www.tardieux-lab.com/
Address: Building Jean Roget, 5th floor, La Tronche, 38000, Grenoble, France
Team head(s): Isabelle Tardieux
Team members: Georgios Pavlou
Isabelle Tardieux

Scientific info

Research domains adhésion/interactions cellulaires
mecanotransduction
migration
pathogènes/parasites
pathologies
trafic intracellulaire
transduction du signal
Organelle/Compartment cytosquelette: microtubules
cytosquelette: actine
cytosquelette: filaments intermédiaires
enveloppe nucléaire
matrice extracellulaire
membrane plasmique
noyau
Techniques biophysique
biosenseurs
cryo-me
culture 3d
culture d’explants
imagerie confocale
imagerie haute resolution (sted, 4pi)
imagerie spinning disk
nanoparticules, quantum dots
videomicroscopie
Cell Models cellules primaires
cellules souches embryonnaires
souris, rat