About
The team entitled “Biomechanics of Host Parasite Interactions” has been created under the lead of I. Tardieux at the Institute for Advanced Biosciences/IAB (INSERM U1209, CNRS UMR 5309, Univ. Grenoble Alpes/UGA). Moving from the Institute Cochin (Paris), IT team continues to develop quantitative high-speed live and high-resolution static imaging to identify and characterize key early processes governing Toxoplasma parasite-host cell interactions while mostly focusing on Toxoplasma motile and invasive skills. The team has been renewed for the 2021_2026 contract by the HCERES-INSERM- CNRS and UGA, and re-entitled “Biomechanics of Host Parasite Interactions. The research IT develops is optimally integrated in a collaborative local network made of (i) physicists from the LIPhy (Laboratory of Interdisciplinary Physics), nanochemists (Department of Molecular Chemistry) (ii) parasitologists and cell mechanobiologists from IAB.
Team info
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Scientific info
Research domains |
adhésion/interactions cellulaires |
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mecanotransduction |
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migration |
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pathogènes/parasites |
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pathologies |
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trafic intracellulaire |
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transduction du signal |
Organelle/Compartment |
cytosquelette: microtubules |
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cytosquelette: actine |
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cytosquelette: filaments intermédiaires |
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enveloppe nucléaire |
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matrice extracellulaire |
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membrane plasmique |
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noyau |
Techniques |
biophysique |
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biosenseurs |
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cryo-me |
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culture 3d |
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culture d’explants |
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imagerie confocale |
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imagerie haute resolution (sted, 4pi) |
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imagerie spinning disk |
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microscopie electronique |
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nanoparticules, quantum dots |
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videomicroscopie |
Cell Models |
cellules primaires |
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cellules souches embryonnaires |
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souris, rat |