Human Immunodeficiency Virus (HIV) infection is a dynamic process involving numerous rounds of infection, replication and cell death. HIV requires multiple interactions with cellular proteins and other cellular components to complete its viral replication cycle while at the same time escaping intracellular antiviral innate restriction mechanisms. Our team focuses on understanding the interplay between HIV and host cellular pathways. Our current research projects focus on two key steps of HIV life cycle: (1) HIV gene expression and (2) viral assembly, budding and release. Our team has a strong expertise in the identification of cellular cofactors of HIV proteins and the characterization of their mechanisms of action. Our work aims at understanding fundamental aspects governing HIV pathogenesis as well as novel cell host functions.
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