Our team investigates how Toxoplasma gondii is able to co-opt specific host cell signaling pathways upon invasion. Along the way, we uncovered novel effector proteins that are singularly exported beyond the vacuole-containing parasites and reach the host cell nucleus to rewire the host genome expression. A second avenue of investigation of our team is to study the epigenetic mechanisms involved in the regulation of the developmental transition between acute and chronic stages of infection. Along the way, we discovered a family of benzoxaborole compounds that efficiently prevent parasite growth.
IAB - Institute for Advanced Biosciences, Université Grenoble Alpes, INSERM U1209, CNRS UMR5309, 38700, GrenobleFRANCE
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