About

I am a senior postdoctoral researcher in the lab of Carsten Janke at the Department of Genotoxic Stress and Cancer, Institut Curie, Orsay-Paris. I have a PhD in biochemistry from the Indian Institute of Science, where I worked on the design and characterization of an immunotoxin for targeted cancer therapy. I applied Biochemical, Molecular Biology and Cell biology approaches to address key questions in understanding the functioning and intracellular trafficking of the immunotoxin. In my postdoctoral research, I moved from targeted therapy to a more basic question on understanding the role of posttranslational modifications of tubulin in the functional diversity of microtubules. More specifically, I am working on understanding the pathopyhsiological implications of glycylation of tubulin, which is a tubulin PTM specific to the axonemes of cilia and flagella. Using mosue as our model organism, I am trying to understand the role of glycylation in cilia stability and function, trying to understand the effect of absence of this particular PTM in cilia diseases, commonly called Ciliopathies.

Team info

Team name: Controlling microtubule dynamics and function with the tubulin code
Affiliated team: Yes
Website: https://institut-curie.org/team/janke
Address: Centre Universitaire, Bat. 110, 91401, Orsay, France
Team head(s): Carsten Janke
Team members: Satish Bodakuntla
Sudarshan Gadadhar
Carsten Janke

Scientific info

Research domains 3R
cycle cellulaire
développement
expression des gènes
signalisation
trafic intracellulaire
transgenics
cell biology
cilia structure and function
Organelle/Compartment cytosquelette: microtubules
cilia and flagella
Techniques imagerie confocale
imagerie spinning disk
primary cell culture from brain
live cell imaging
Cell Models cellules primaires
lignees cellulaires
souris, rat