Sudarshan Gadadhar

I am a senior postdoctoral researcher in the lab of Carsten Janke at the Department of Genotoxic Stress and Cancer, Institut Curie, Orsay-Paris. I have a PhD in biochemistry from the Indian Institute of Science, where I worked on the design and characterization of an immunotoxin for targeted cancer therapy. I applied Biochemical, Molecular Biology and Cell biology approaches to address key questions in understanding the functioning and intracellular trafficking of the immunotoxin. In my postdoctoral research, I moved from targeted therapy to a more basic question on understanding the role of posttranslational modifications of tubulin in the functional diversity of microtubules. More specifically, I am working on understanding the pathopyhsiological implications of glycylation of tubulin, which is a tubulin PTM specific to the axonemes of cilia and flagella. Using mosue as our model organism, I am trying to understand the role of glycylation in cilia stability and function, trying to understand the effect of absence of this particular PTM in cilia diseases, commonly called Ciliopathies.