About
The team entitled “Biomechanics of Host Parasite Interactions” has been created under the lead of I. Tardieux at the Institute for Advanced Biosciences/IAB (INSERM U1209, CNRS UMR 5309, Univ. Grenoble Alpes/UGA). Moving from the Institute Cochin (Paris), IT team continues to develop quantitative high-speed live and high-resolution static imaging to identify and characterize key early processes governing Toxoplasma parasite-host cell interactions while mostly focusing on Toxoplasma motile and invasive skills. The team has been renewed for the 2021_2026 contract by the HCERES-INSERM- CNRS and UGA, and re-entitled “Biomechanics of Host Parasite Interactions. The research IT develops is optimally integrated in a collaborative local network made of (i) physicists from the LIPhy (Laboratory of Interdisciplinary Physics), nanochemists (Department of Molecular Chemistry) (ii) parasitologists and cell mechanobiologists from IAB.
Team info
Scientific info
Research domains |
adhésion/interactions cellulaires |
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mecanotransduction |
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migration |
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pathogènes/parasites |
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pathologies |
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trafic intracellulaire |
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transduction du signal |
Organelle/Compartment |
cytosquelette: microtubules |
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cytosquelette: actine |
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cytosquelette: filaments intermédiaires |
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enveloppe nucléaire |
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matrice extracellulaire |
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membrane plasmique |
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noyau |
Techniques |
biophysique |
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biosenseurs |
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cryo-me |
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culture 3d |
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culture d’explants |
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imagerie confocale |
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imagerie haute resolution (sted, 4pi) |
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imagerie spinning disk |
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microscopie electronique |
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nanoparticules, quantum dots |
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videomicroscopie |
Cell Models |
cellules primaires |
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cellules souches embryonnaires |
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lignees cellulaires |
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souris, rat |