Host lab: Chlamydia trachomatis is a human-adapted pathogen and develops exclusively inside a vacuolar compartment. It is the leading cause of sexually transmitted infection of bacterial origin. The Subtil lab investigates how the bacteria manipulate the host cell to establish a beneficial replication niche. Our recent studies have characterized some of the consequences of infection on host cell intracellular traffic, on host metabolism, on chromatin integrity and on the innate response to infection.

Project: The bacteria manipulate intracellular traffic to build its own replication niche. The successful candidate will investigate FcRn-mediated transport of immunoglobulins in polarized epithelial cells infected with Chlamydia trachomatis. The effects of immunoglobulins against specific bacterial antigens on the course of infection will be studied to identify suitable vaccine candidates. This project is led in collaboration with Sanofi Pasteur.

Environment: The applicant will benefit from a highly collaborative, dynamic and international environment at Institut Pasteur within center Paris. The Subtil lab is associated with the Cell Biology and Infection department (18 teams). The Institut Pasteur hosts 13 departments (142 teams) and counts 15 technological platforms.

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– PhD in cell biology, withe large experience in microscopy techniques and image analysis.

– An experience in models of polarized epithelial cells is a plus but is not essential.

Salary: based on experience following Institut Pasteur grids.

To apply: submit a cover letter containing a statement of interests and future goals, a CV with a list of publications and names of two references from mentors to

Starting date: The position is available immediately and will remain open until filled. The expected start date is April or May 2022.

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