Project: Chlamydia trachomatis is a human-adapted pathogen that develops exclusively inside a vacuolar compartment. The host lab has gathered evidence that these bacteria hijacked the trafficking machinery implicated in the formation of Lysosome-Related Organelles (LROs) to build their vacuole. LROs are organelles that share features with lysosomes, though being not degradative. Defects in LRO biogenesis are associated to a number of syndromic disorders , e.g. in skin pigmentation, blood coagulation, immune or lung functions. The main aim of the present project is to exploit the bacteria as a tool to delineate the membrane trafficking pathways needed for LRO biogenesis, and to identify molecules that interfere with this process, with potential application in drug development. Candidate: The post-doc, a highly motivated research fellow, will have a strong background in cell biology. The project will use experimental approaches of cell biology and molecular biology with an emphasis on state-of-the-art optical and electron microscopy techniques. Location: The Institut Pasteur in Paris offers an international, dynamic and stimulating scientific campus. This project will be led in close collaboration with Dr. C. Delevoye in the laboratory of Graça Raposo at Institut Curie, also in Paris. Starting date: Oct. 1st 2021. Send applications (cover letter, CV and contact phone/email of two referees) to Agathe Subtil.
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