Pablo VARGAS

Dr< Pablo Vargas is a leading immunologist and cell biologist whose research over the past two decades has significantly advanced our understanding of the cellular and molecular mechanisms governing immune cell migration. Vargas and colleagues have focused extensively on the dynamic regulation of the actin cytoskeleton, cell polarity, and organelle positioning that enable dendritic cells, neutrophils, and T cells to efficiently migrate through complex and confined tissue environments. Since 2022, Dr. Vargas is the group leader of the Leukomotion Lab at the Institut Necker-Enfants Malades (INEM) in Paris, where his team investigates the fundamental biophysical and molecular mechanisms enabling leukocytes to migrate through complex tissue environments. The lab employs multidisciplinary approaches combining advanced microscopy, microfabrication, organ-on-chip and mechanobiology to explore how cytoskeletal dynamics, nuclear mechanics, organelle trafficking and signaling pathways coordinate immune cell motility. The research also aims to understand how impaired migration contributes to immune dysfunction in human diseases, bridging basic science with clinical relevance.