Marie-Jo Moutin

Crosstalk between acetylation and the tyrosination/detyrosination cycle of α-tubulin in Alzheimer's disease. Martínez-Hernández J, Parato J, Sharma A, Soleilhac JM, Qu X, Tein E, Sproul A, Andrieux A, Goldberg Y, Moutin MJ, Bartolini F, Peris L. Front Cell Dev Biol. 2022 Aug 26;10:926914. doi: 10.3389/fcell.2022.926914. eCollection 2022. PMID: 36092705 Posttranslational modification of microtubules by the MATCAP detyrosinase. Landskron L, Bak J, Adamopoulos A, Kaplani K, Moraiti M, van den Hengel LG, Song JY, Bleijerveld OB, Nieuwenhuis J, Heidebrecht T, Henneman L, Moutin MJ, Barisic M, Taraviras S, Perrakis A, Brummelkamp TR. Science. 2022 May 20;376(6595):eabn6020. doi: 10.1126/science.abn6020. Epub 2022 May 20. PMID: 35482892 VASH1-SVBP and VASH2-SVBP generate different detyrosination profiles on microtubules. Ramirez-Rios S, Choi SR, Sanyal C, Blum TB, Bosc C, Krichen F, Denarier E, Soleilhac JM, Blot B, Janke C, Stoppin-Mellet V, Magiera MM, Arnal I, Steinmetz MO, Moutin MJ. J Cell Biol. 2023 Feb 6;222(2):e202205096. doi: 10.1083/jcb.202205096. PMID: 36512346 Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease. Peris L, Parato J, Qu X, Soleilhac JM, Lanté F, Kumar A, Pero ME, Martínez-Hernández J, Corrao C, Falivelli G, Payet F, Gory-Fauré S, Bosc C, Blanca Ramirez M, Sproul A, Brocard J, Di Cara B, Delagrange P, Buisson A, Goldberg Y, Moutin MJ, Bartolini F, Andrieux A. Brain. 2022 Jul 29;145(7):2486-2506. doi: 10.1093/brain/awab436. PMID: 35148384 The detyrosination/re-tyrosination cycle of tubulin and its role and dysfunction in neurons and cardiomyocytes. Sanyal C, Pietsch N, Ramirez Rios S, Peris L , Carrier L , Moutin MJ. Semin Cell Dev Biol 2021 Dec 16;S1084-9521(21)00314-1. doi: 10.1016/j.semcdb.2021.12.006. Tubulin post-translational modifications control neuronal development and functions. Moutin MJ, Bosc C, Peris L, Andrieux A. Dev Neurobiol. 2020 Jul 22. doi: 10.1002/dneu.22774. Review. Defective tubulin detyrosination causes structural brain abnormalities with cognitive deficiency in humans and mice. Pagnamenta AT*, Heemeryck P*, Martin HC*, Bosc C, Peris L, Uszynski I, Gory-Fauré S, Couly S, Deshpande C, Siddiqui A, Elmonairy AA, Jayawant S, Murthy S, Walker I, Loong L, Bauer P, Vossier F, Denarier E, Maurice T, Barbier EL, Deloulme JC, Taylor JC, Blair EM#, Andrieux A, Moutin MJ#. Hum Mol Genet. 2019 Oct 15;28(20):3391-3405. doi: 10.1093/hmg/ddz186. Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex. Wang N*, Bosc C*, Ryul Choi S*, Boulan B, Peris L, Olieric N, Bao H, Krichen F, Chen L, Andrieux A, Olieric V, Moutin MJ#, Steinmetz MO#, Huang H#. Nat Struct Mol Biol. 2019 Jul;26(7):571-582. doi: 10.1038/s41594-019-0241-y. Scientific Reports 2018 b, Feb 15;8(1):3072. doi: 10.1038/s41598-018-21470-2 Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation. Aillaud C, Bosc C, Peris L, Bosson A, Heemeryck P, Van Dijk J, Le Friec J, Boulan B, Vossier F, Sanman LE, Syed S, Amara N, Couté Y, Lafanechère L, Denarier E, Delphin C, Pelletier L, Humbert S, Bogyo M, Andrieux A, Rogowski K, Moutin MJ. Science. 2017 Dec 15;358(6369):1448-1453. doi: 10.1126/science.aao4165. PMID: 29146868 Evidence for new C-terminally truncated variants of α- and β-tubulins. Aillaud C, Bosc C, Saoudi Y, Denarier E, Peris L, Sago L, Taulet N, Cieren A, Tort O, Magiera M, Janke C, Redeker V, Andrieux A, Moutin MJ. Mol Biol Cell. 2016 Feb 15;27(4):640-53