About

I hold a PhD in Neurophysiology and Clinical and Experimental Neurosciences, which I obtained in 2016 from the University 'La Sapienza' in Rome. My thesis focused on the involvement of microglial cells in brain development and depressive-like behaviors. After completing my PhD, I joined the Brain and Spine Institute (ICM) in Paris, where I conducted pioneering research on a new living model of the human brain, studying the role of microglial cells in the onset of epilepsy. In 2019, I moved to the Collège de France, working in Dr. Nathalie Rouach's laboratory, where I explored the role of astrocytes in epilepsy using imaging and electrophysiology techniques. I was recently recruited as a tenured researcher at the Molecular Imaging Research Center (CEA), where I am starting my own research group focusing on the role of the gut microbiota–glia axis in human brain development and epilepsy. I am currently refining a new 3D ex vivo model of the human brain that allows for various genetic manipulations of glial cells, with the aim of developing new therapeutic strategies against epilepsy.

Team info

Team name: Team Nathalie Rouach
Affiliated team: No
Website: https://jacob.cea.fr/drf/ifrancoisjacob/Pages/Departements/MIRCen/themes/interactions-cellulaires-modeles-biotherapies.aspx
Address: (FR) 18 route du Panorama, (FR) 92265, (FR) Fontenay aux Roses

Scientific info

Research domains biologie des systèmes
neurobiologie
pathologies
signalisation
Techniques biophysique
culture d’explants
imagerie confocale
imagerie frap, flim, fret, etc
imagerie multiphotons
Cell Models cellules primaires