About

Bruno Mesmin, a tenured Inserm researcher at the Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), CNRS–Université Côte d’Azur (France), is a cell biologist and biochemist internationally recognized for his expertise in membrane biology and lipid transport. He made a seminal contribution to the field with Mesmin et al., Cell 2013, which established a new model for non-vesicular lipid trafficking at membrane contact sites (MCS). More recently, his team elucidated how specific regions of the VAPA protein confer structural flexibility, enabling efficient and adaptable membrane tethering at contact sites (Subra et al., Dev Cell 2023). His research further explores the role of VAP proteins in physiopathology, as well as intracellular cholesterol transport and regulation in mammalian cells. More recently, he has also become interested in how these cellular pathways are hijacked by flaviviruses, including Zika virus.

Team info

Team name: Dynamique des membranes et manteaux protéiques
Affiliated team: Yes
Website: https://intra.ipmc.cnrs.fr
Address: Route des Lucioles, 6560, Valbonne, FRANCE
Team head(s): Bruno Antonny

Scientific info

Research domains pathogènes/parasites
pathologies
signalisation
trafic intracellulaire
Organelle/Compartment appareil de golgi/tgn
endosomes/lysosomes
membrane plasmique
réticulum
Techniques biophysique
biosenseurs
imagerie confocale
imagerie frap, flim, fret, etc
imagerie haute resolution (sted, 4pi)
imagerie spinning disk
microscopie electronique
systemes in vitro
videomicroscopie
Cell Models cellules primaires
lignees cellulaires