The Kodjabachian lab at the Institute of Developmental Biology of Marseille (IBDM) is seeking a young and talented postdoctoral scientist with strong background in cell and developmental biology, and a keen interest in integrative quantitative biology and interdisciplinary research. Our lab uses advanced imaging techniques (such as confocal videomicroscopy, super-resolution microscopy and 3D electron microscopy) to study the biology of ciliated epithelia at multiple scales.
In vertebrate ciliated epithelia, flows of biological fluids are powered by the coordinated beating of myriads of cilia harbored by multiciliated cells (MCC). In recent years, the global MCC transcriptome has been decrypted in Xenopus, mouse and human. Through this project, funded by ANR, we now wish to elucidate the functional MCC proteome. The selected candidate will be in charge of testing the functional importance of candidates selected through proteomic screens currently running in the team. He/she will use Xenopus epidermis, inducible MCC culture, and mouse post-natal brain as models to elucidate the mechanisms underlying vertebrate MCC construction.
IBDM offers a vibrant, international, and interactive environment to study the fundamental principles of cell and developmental biology. IBDM is also part of the Turing Center for Living Systems (CENTURI), a large interdisciplinary program allowing rich collaboration with theoreticians, physicists and computer scientists.
The ideal candidate must hold a PhD for less than two years, and have skills in cell culture, cell imaging, molecular biology, and biochemistry. The position is opened for one year renewable up to 3 years starting as early as January 2021. Applicants must email a CV, a statement of interest and contact details for 2-3 references to laurent.kodjabachian@univ-amu.fr.
http://www.ibdm.univ-mrs.fr/equipe/biology-of-ciliated-epithelia/
Relevant publications:
- Loiseau et al., 2020. Nature Physics
- Boutin and Kodjabachian. Current Opinion in Genetics and Development
- Revinski et al. 2018. Nature Communications
- Chevalier et al. 2015. Nature Communications
- Cibois et al. 2015. Development
- Marcet et al. 2011. Nature Cell Biology
