Context: Many pathogens are difficult to eradicate, even in the absence of genetically encoded antimicrobial resistance mechanisms and despite remaining susceptible to antibiotics in vitro. A subset of clonal bacteria can transiently withstand antibiotic treatment; these cells are known as antibiotic persisters. Growing evidence suggests that the host immune cell environment, particularly within macrophages, plays …

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Targeting antimicrobial resistance through bacterial adhesin research Strains, Diagnostics, and Variants StraDiVarious is a European doctoral network studying strain variants of ESKAPE pathogens to develop rapid diagnostics and identify therapeutic targets. Our research hypothesis is: small structural variations in virulence factors modulate the virulence of different bacterial strains of the same species, and, in turn, …

Continuer à lire “EU funded PhD position at Institut Pasteur DC7: Impact of microenvironment on colonisation and virulence of enteric bacteria”