À propos

I joined Sophie Polo‘s team in September 2017 as a postdoctoral fellow. During my PhD at San Raffaele Scientific Institute in Milan, Italy, I identified a new role for the histone demethylase JARID1C in the maintenance of genome stability through heterochromatin condensation after DNA replication. I also characterized that JARID1C has a role in DNA replication origin firing. I then moved to the Dana Farber Cancer Institute in Boston, MA, where, under the supervision of Alan D’Andrea, I characterized a new mechanism of chemoresistance in BRCA2-deficient tumors that is mediated by the downregulation of EZH2 activity at stalled replication forks, which in turn abolishes the activity of the endonuclease MUS81. In Sophie Polo‘s lab, I am studying the role of histone H3.3 oncogenic mutations in inducing genomic instability in human tumors, with the support of a Marie Curie reintegration grant. I obtained a permanent staff scientist position (CNRS) in 2018.

Informations concernant l'équipe

Nom de l'équipe : Epigenome integrity
Équipe affiliée : Oui
Site web : http://parisepigenetics.com/ei-en/
Adresse : 35 rue Hélène Brion, 75013, Paris, France
Responsable(s) de l'équipe : Sophie Polo
Membres de l'équipe : Beatrice Rondinelli
Sophie Polo
Anna Fortuny González

Informations scientifiques

Domaines de recherche 3R
Organite/ Compartiment noyau
Techniques cribles d’interactions
systemes in vitro
Modèles cellulaires cellules primaires
lignees cellulaires