Our projects aim at understanding the tumor microenvironment of aggressive cancers, especially malignant pleural mesothelioma and lung cancer, to develop innovative therapeutic strategies by combining their direct cytotoxicity with induction of specific antitumor immune responses.

To improve and develop our innovative therapies, our goal is to better understand the tumor microenvironment of thoracic cancers including endothelial cell, macrophages, direct cell-cell interactions, soluble factors, non-coding RNAs and extracellular vesicles.

On the ground of our interests for molecular piracy exerted by tumor cells to survive, adapt and remodel their environment, we explore the signaling mechanisms involved in non-oncogene addiction and loss of vascular homeostasis.