Project: We are looking for a highly motivated post-doc interested in molecular and cellular membrane biology. The research will focus on the study of lipid transport pathways at membrane contact sites between the endoplasmic reticulum (ER) and endolysosomal compartments, more specifically lamellar bodies (LBs), which are responsible for pulmonary surfactant biogenesis in alveolar epithelial type-II …

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Context: Many pathogens are difficult to eradicate, even in the absence of genetically encoded antimicrobial resistance mechanisms and despite remaining susceptible to antibiotics in vitro. A subset of clonal bacteria can transiently withstand antibiotic treatment; these cells are known as antibiotic persisters. Growing evidence suggests that the host immune cell environment, particularly within macrophages, plays …

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Targeting antimicrobial resistance through bacterial adhesin research Strains, Diagnostics, and Variants StraDiVarious is a European doctoral network studying strain variants of ESKAPE pathogens to develop rapid diagnostics and identify therapeutic targets. Our research hypothesis is: small structural variations in virulence factors modulate the virulence of different bacterial strains of the same species, and, in turn, …

Continuer à lire “EU funded PhD position at Institut Pasteur DC7: Impact of microenvironment on colonisation and virulence of enteric bacteria”