Nathalie Sauvonnet

1. 4D live imaging and computational modeling of a functional gut-on-a-chip evaluate how peristalsis facilitates enteric pathogen invasion.Boquet-Pujadas A, Feaugas T, Petracchini A, Grassart A, Mary H, Manich M, Gobaa S, Olivo-Marin JC, Sauvonnet N, Labruyère E. Sci Adv. 2022 Oct 21;8(42):eabo5767. doi: 10.1126/sciadv.abo5767. Epub 2022 Oct 21. PMID: 36269830 Free PMC article. 2 Tracking receptor motions at the plasma membrane reveals distinct effects of ligands on CCR5 dynamics depending on its dimerization status. Momboisse F, Nardi G, Colin P, Hery M, Cordeiro N, Blachier S, Schwartz O, Arenzana-Seisdedos F, Sauvonnet N, Olivo-Marin JC, Lagane B, Lagache T, Brelot A. Elife. 2022 Jul 22;11:e76281. doi: 10.7554/eLife.76281. PMID: 35866628 Free PMC article. 3 High prevalence of small intestine bacteria overgrowth and asymptomatic carriage of enteric pathogens in stunted children in Antananarivo, Madagascar. Collard JM, Andrianonimiadana L, Habib A, Rakotondrainipiana M, Andriantsalama P, Randriamparany R, Rabenandrasana MAN, Weill FX, Sauvonnet N, Randremanana RV, Guillemot V, Vonaesch P, Sansonetti PJ; Afribiota Investigators. PLoS Negl Trop Dis. 2022 May 9;16(5):e0009849. doi: 10.1371/journal.pntd.0009849. eCollection 2022 May. PMID: 35533199 Free PMC article. 4 A virus-derived microRNA targets immune response genes during SARS-CoV-2 infection. Singh M, Chazal M, Quarato P, Bourdon L, Malabat C, Vallet T, Vignuzzi M, van der Werf S, Behillil S, Donati F, Sauvonnet N, Nigro G, Bourgine M, Jouvenet N, Cecere G. EMBO Rep. 2022 Feb 3;23(2):e54341. doi: 10.15252/embr.202154341. Epub 2021 Dec 16. PMID: 34914162 Free PMC article. 5 Cytokine receptor cluster size impacts its endocytosis and signaling. Salavessa L, Lagache T, Malardé V, Grassart A, Olivo-Marin JC, Canette A, Trichet M, Sansonetti PJ, Sauvonnet N. Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2024893118. doi: 10.1073/pnas.2024893118. PMID: 34504012 Free PMC article. 6 Organ-on-chip to investigate host-pathogens interactions. Feaugas T, Sauvonnet N. Cell Microbiol. 2021 Jul;23(7):e13336. doi: 10.1111/cmi.13336. Epub 2021 Apr 22. PMID: 33798273 Review. 7 Stoichiometry of Receptors at the Plasma Membrane During Their Endocytosis Using Total Internal Reflection Fluorescent (TIRF) Microscopy Live Imaging and Single-Molecule Tracking. Salavessa L, Sauvonnet N. Methods Mol Biol. 2021;2233:3-17. doi: 10.1007/978-1-0716-1044-2_1. PMID: 33222124 8 Bioengineered Human Organ-on-Chip Reveals Intestinal Microenvironment and Mechanical Forces Impacting Shigella Infection. Grassart A, Malardé V, Gobaa S, Sartori-Rupp A, Kerns J, Karalis K, Marteyn B, Sansonetti P, Sauvonnet N. Cell Host Microbe. 2019 Oct 9;26(4):565. doi: 10.1016/j.chom.2019.09.007. PMID: 31600505 Free article. No abstract available. 9 Bioengineered Human Organ-on-Chip Reveals Intestinal Microenvironment and Mechanical Forces Impacting Shigella Infection. Grassart A, Malardé V, Gobaa S, Sartori-Rupp A, Kerns J, Karalis K, Marteyn B, Sansonetti P, Sauvonnet N. Cell Host Microbe. 2019 Sep 11;26(3):435-444.e4. doi: 10.1016/j.chom.2019.08.007. Epub 2019 Sep 3. PMID: 31492657 Free article. 10 Shigella promotes major alteration of gut epithelial physiology and tissue invasion by shutting off host intracellular transport. Ferrari ML, Malardé V, Grassart A, Salavessa L, Nigro G, Descorps-Declere S, Rohde JR, Schnupf P, Masson V, Arras G, Loew D, Sansonetti PJ, Sauvonnet N. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13582-13591. doi: 10.1073/pnas.1902922116. Epub 2019 Jun 17. PMID: 31209035 Free PMC article. Lagache T, Grassart A, Dallongeville S, Faklaris O, Sauvonnet N, Dufour A, Danglot L, Olivo-Marin JC. 2018. Mapping molecular assemblies with fluorescence microscopy and object-based spatial statistics. Nat Commun. 2018 Feb 15;9(1):698 11 Bertot L, Grassart A, Lagache T, Nardi G, Basquin C, Olivo-Marin JC, Sauvonnet N. 2018. Quantitative and Statistical Study of the Dynamics of Clathrin-Dependent and -Independent Endocytosis Reveal a Differential Role of EndophilinA2. Cell Rep. 2018 Feb 6;22(6):1574-1588 12 Bonvicini A, Guilhaudis L, Tognetti V, Desmaële D, Sauvonnet N, Oulyadi H, Joubert L. 2018. Revisiting absorption and electronic circular dichroism spectra of cholesterol in solution: a joint experimental and theoretical study. Phys Chem Chem Phys. 2018 Feb 14;20(7):5274-5284. 13 Fernandez-Garcia MD, Meertens L, Chazal M, Hafirassou ML, Dejarnac O, Zamborlini A, Despres P, Sauvonnet N, Arenzana-Seisdedos F, Jouvenet N, Amara A. Vaccine and Wild-Type Strains of Yellow Fever Virus Engage Distinct Entry Mechanisms and Differentially Stimulate Antiviral Immune Responses. MBio. 2016 Feb 9;7(1):e01956-15. 14 Basquin C, Trichet M, Vihinen H, Malardé V, Lagache T, Ripoll L, Jokitalo E, Olivo-Marin JC, Gautreau A, Sauvonnet N. 2015. Membrane protrusion powers clathrin-independent endocytosis of interleukin-2 receptor. EMBO J. 2015 Aug 13;34(16):2147-61 15 Lagache T, Sauvonnet N, Danglot L, Olivo-Marin JC. 2015. Statistical analysis of molecule colocalization in bioimaging. Cytometry A. 2015 Jan 20. 16 Boucrot E, Ferreira A, Almeida-Souza A, Vallis Y, Howard G, Debard S, Bertot L, Sauvonnet N and McMahon HT. 2015 "Endophilin marks and controls a clathrin-independent endocytic pathway" Nature. 2015 Jan 22;517(7535):460-5 17 Boissan M, Montagnac G, Guitton J, Romao M, Sauvonnet N, Lagache T, Lascu I, Raposo G, Lacombe ML, Polo S, Roux A and Chavrier P. A 2014 Nucleoside Diphosphate Kinase fuels Dynamin with GTP for efficient endocytosis. SCIENCE 2014 Jun 27;344(6191):1510-5 18 Jin J, Colin P, Staropoli I, Lima-Fernandes E, Ferret C, Demir A, Rogee S, Hartley O, Randriamampita C, Scott M, Marullo S, Sauvonnet N, Arenzana-Seisdedos F, Lagane B and Brelot A. 2014 Targeting Spare CCR5 as a Principle to Inhibit HIV-1 J Biol Chem. 2014 Jul 4;289(27):19042-52 19 Lagache T, Lang G, Sauvonnet N and Olivo-Marin JC. 2013 Analysis of the Spatial Organization of Molecules with Robust Statistics PLOS ONE, 2013 Dec 4;8(12) 20 Basquin C, Sauvonnet N. 2013. Phosphoinositide 3-kinase at the crossroad between endocytosis and signaling of cytokine receptors. Commun Integr Biol. Jul 1;6(4) 21 Basquin C, Malardé V, Mellor P, Anderson DA, Meas-Yedid V, Olivo-Marin JC, Dautry-Varsat, A, Sauvonnet N. 2013. The signaling factor PI 3-kinase is a specific regulator of the clathrin-independent dynamin-dependent endocytosis of IL-2 receptors. J Cell Sci. (126):1099-1108 22 Wigelsworth DJ, Ruthel G, Schnell L, Herrlich P, Blonder J, Veenstra TD, Carman RJ, Wilkins TD, Van Nhieu GT, Pauillac S, Gibert M, Sauvonnet N, Stiles BG, Popoff MR, Barth H. 2012. CD44 Promotes Intoxication by the Clostridial Iota-Family Toxins. PLoS One.;7(12):e51356. 23 Mounier J, Boncompain G, Senerovic L, Lagache T, Chrétien F, Perez F, Kolbe M, Olivo-Marin JC, Sansonetti, P, Sauvonnet, N. 2012. Cholesterol relocation induced by the Shigella virulence factor IpaB inhibits host cell secretion by disrupting the Golgi complex and recycling network. Cell Host and Microbe, Sep 13;12(3):381-9.