À propos
After defending her doctoral thesis in 1991 at the Université Pierre et Marie Curie on the cellular differentiation of neurons, Valérie Doye undertook a post-doctorate until 1994 at the European Molecular Biology Laboratory (Heidelberg, Germany). There, she specialized in the components of nuclear pores, nucleoporins, and their role in transport between cytoplasm and nucleus. In 1994, she joined the CNRS, then developed her research team at the Institut Curie, where she characterized the role of nucleoporins in nuclear pore assembly, as well as some of their unconventional functions in cell division and genome integrity. In 2008, she moved her team to the Institut Jacques Monod. In 2009, she was awarded the CNRS Silver Medal for her research work. Head of the cell biology program and member of the Institut Jacques Monod management committee, she became deputy director in 2020 and director of the Institute as of september 2023.
Currently, the Doye team is studying the functions of nucleoporins in nuclear pore assembly, signaling and gene regulation during cell differentiation. To this end, the team uses pluripotent stem cells and their differentiated derivatives, notably in the form of organoids. This work should help us to understand why, despite the universal role of nuclear pores in all nucleated cells, certain nucleoporins are linked to human hereditary diseases affecting specific cell types and organs.