The CeDRE team at the Institute of Genetics and Development of Rennes (IGDR) studies the robustness and the mechanics of cell division adapting. Indeed, this process is surprisingly faithful, correctly partitioning the chromosomes and organelles to the daughter cells, despite chromosomal defects and external perturbations (cell shape or environment changes). We envision that beyond the biochemical regulations, the assembly of molecular motors and microfilaments interacts into a complex mechanical system to achieve that goal. Combining advanced microscopy, image and data analyses with cell biology using the nematode model, we previously uncovered such mechanisms in spindle positioning. We now set to focus on the spindle itself and its chromosome partitioning function. The lab offers a stimulating interdisciplinary environment. Beyond the fundamental research using C.elegans, we also develop autonomous microscopy fostered by deep learning algorithms in a public-private collaboration to challenge our findings in human cells and beyond.
Membres de l'équipe
