The central goal of our team is to understand how the excitability of neurons and muscles is regulated by basic molecular and cellular processes that control the biology of potassium-selective ion channels.
To identify novel genes and conserved cellular processes that regulate the biology of potassium channels in vivo, we take advantage of the powerful genetic tools available in the model nematode Caenorhabditis elegans. We use the full array of techniques available in C. elegans including genetics, live imaging, electrophysiology and state-of-the-art CRISPR/Cas9 genome engineering and next-generation DNA sequencing.
