À propos
Bruno Mesmin, a tenured Inserm researcher at the Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), CNRS–Université Côte d’Azur (France), is a cell biologist and biochemist internationally recognized for his expertise in membrane biology and lipid transport. He made a seminal contribution to the field with Mesmin et al., Cell 2013, which established a new model for non-vesicular lipid trafficking at membrane contact sites (MCS). More recently, his team elucidated how specific regions of the VAPA protein confer structural flexibility, enabling efficient and adaptable membrane tethering at contact sites (Subra et al., Dev Cell 2023).
His research further explores the role of VAP proteins in physiopathology, as well as intracellular cholesterol transport and regulation in mammalian cells. More recently, he has also become interested in how these cellular pathways are hijacked by flaviviruses, including Zika virus.
Informations concernant l'équipe
Informations scientifiques
| Domaines de recherche |
pathogènes/parasites |
|
pathologies |
|
signalisation |
|
trafic intracellulaire |
| Organite/ Compartiment |
appareil de golgi/tgn |
|
endosomes/lysosomes |
|
membrane plasmique |
|
réticulum |
| Techniques |
biophysique |
|
biosenseurs |
|
imagerie confocale |
|
imagerie frap, flim, fret, etc |
|
imagerie haute resolution (sted, 4pi) |
|
imagerie spinning disk |
|
microscopie electronique |
|
systemes in vitro |
|
videomicroscopie |
| Modèles cellulaires |
cellules primaires |
|
lignees cellulaires |