À propos

Bruno Mesmin, a tenured Inserm researcher at the Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), CNRS–Université Côte d’Azur (France), is a cell biologist and biochemist internationally recognized for his expertise in membrane biology and lipid transport. He made a seminal contribution to the field with Mesmin et al., Cell 2013, which established a new model for non-vesicular lipid trafficking at membrane contact sites (MCS). More recently, his team elucidated how specific regions of the VAPA protein confer structural flexibility, enabling efficient and adaptable membrane tethering at contact sites (Subra et al., Dev Cell 2023). His research further explores the role of VAP proteins in physiopathology, as well as intracellular cholesterol transport and regulation in mammalian cells. More recently, he has also become interested in how these cellular pathways are hijacked by flaviviruses, including Zika virus.

Informations concernant l'équipe

Nom de l'équipe : Dynamique des membranes et manteaux protéiques
Équipe affiliée : Oui
Site web : https://intra.ipmc.cnrs.fr
Adresse : Route des Lucioles, 6560, Valbonne, FRANCE
Responsable(s) de l'équipe : Bruno Antonny

Informations scientifiques

Domaines de recherche pathogènes/parasites
pathologies
signalisation
trafic intracellulaire
Organite/ Compartiment appareil de golgi/tgn
endosomes/lysosomes
membrane plasmique
réticulum
Techniques biophysique
biosenseurs
imagerie confocale
imagerie frap, flim, fret, etc
imagerie haute resolution (sted, 4pi)
imagerie spinning disk
microscopie electronique
systemes in vitro
videomicroscopie
Modèles cellulaires cellules primaires
lignees cellulaires