Beatrice Rondinelli

I joined Sophie Polo‘s team in September 2017 as a postdoctoral fellow. During my PhD at San Raffaele Scientific Institute in Milan, Italy, I identified a new role for the histone demethylase JARID1C in the maintenance of genome stability through heterochromatin condensation after DNA replication. I also characterized that JARID1C has a role in DNA replication origin firing. I then moved to the Dana Farber Cancer Institute in Boston, MA, where, under the supervision of Alan D’Andrea, I characterized a new mechanism of chemoresistance in BRCA2-deficient tumors that is mediated by the downregulation of EZH2 activity at stalled replication forks, which in turn abolishes the activity of the endonuclease MUS81. In Sophie Polo‘s lab, I am studying the role of histone H3.3 oncogenic mutations in inducing genomic instability in human tumors, with the support of a Marie Curie reintegration grant. I obtained a permanent staff scientist position (CNRS) in 2018.