Understanding brain compensation systems may open new avenues to fighting neurodegenerative diseases and age-related pathologies.

Our team combines two interdisciplinary approaches to model the behaviour of molecular regulatory networks.
The first approach leans on the development of the software suite RSAT ( devoted to the analysis of functional genomic data (ChIP-seq, transcriptome) in order to delineate cis-regulatory regions (promoters, enhancers) and their role in the control of gene expression.
The second approach leans on the development of the software GINsim ( devoted to the dynamical modelling and the analysis or large signalling/regulatory networks.
These methodological developments are motivated by and applied to the study of regulatory networks controlling cell specification, differentiation and reprogramming in animals, in particular of cells of the immune system, in close collaboration with several experimental teams.
Tools and models are systematically made available to the scientific community.

Epithelial cells which cover external and internal surfaces of the body and of all organs perform essential functions such as barrier, absorption, filtration or respiration. These functions requires the establishment and the maintenance of a cell polarity specific to epithelial cells. Using C. elegans our team seeks to identify and characterise the key factors essential for the maintenance of epithelial polarity in two contexts:

  • how membrane traffic controls epithelial polarity and food absorption in the intestine.
  • how a biomechanical signaling pathway controls embryonic morphogenesis.

Le fonctionnement des systèmes nerveux et neuroendocrine repose sur une communication cellulaire élaborée assurée par un intense trafic membranaire (exocytose, endocytose, autophagie, phagocytose). Le but de nos recherches est d’en décrypter les mécanismes moléculaires dont l’altération est à la base de pathologies (maladies neurodégénératives, retard mental, cancers neuroendocrines). Pour cela nous étudions spécifiquement le rôle des protéines d’arrimage et de fusion membranaire, ainsi que la formation des domaines lipidiques et l’organisation du cytosquelette.