Kinetochores are highly specialized protein structures assembled on centromeric chromatin during mitotic and meiotic cell division. These macromolecular structures serve as the chromosomal attachment sites for connection to spindle microtubules, which drive chromosome congression and segregation into daughter cells. The hundreds of kinetochore proteins identified fulfill a wide range of critical functions including specification of centromeric chromatin, powering chromosome movements, regulation of spindle microtubule dynamics, and checkpoint signaling. The objective of this meeting is to bring together new investigators as well as established kinetochore researchers to present their new findings, learn about the latest unpublished research, and build new collaborations.
Topics include:
• Centromere specification
• Kinetochore structure and function
• Regulation and mechanics of kinetochore-microtubule interactions
• Spindle assembly checkpoint
• Diversity of chromosome segregation mechanisms
Keynote speaker:
Arshad Desai, Ludwig Institute for Cancer Research, San Diego, US
Speakers:
Binyam Mogessie; University Walk, Bristol, UK
Chris Campbell; Max F. Perutz Laboratories, AT
Alexander Kelly; National Cancer Institute/NIH, US
Karen Schindler; Rutgers, The State University of NJ, US
Hong Liu; Tulane School of Medicine, New Orleans, US
Karen Wing Yee Yuen; The University of Hong Kong, HK
Bill Wickstead; University of Nottingham, UK
Julie Welburn; Wellcome Trust Centre for Cell Biology, UK
Elaine Dunleavy; National University of Ireland, IR
Helder Maiato; Universidade do Porto, PT
Patrick Heun; Wellcome Trust Centre for Cell Biology, UK
Lars Jansen; Institute Gulbenkian, PT
Jakob Nilsson, University of Copenhagen, DK
Tom Maresca; University of Massachusetts Amherst, US
Soni Lacefield; Indiana University, US
Barbara Mellone; University of Connecticut, Storrs, US
Ben Black; University of Pennsylvania, US
Ekaterina Grishchuk; University of Pennsylvania, US
Phong Tran; Institut Curie, FR
Organizers:
Jennifer DeLuca (Colorado State University, US)
Ines Anna Drinnenberg (Institut Curie, FR)
Bungo Akiyoshi (University of Oxford, UK)
Julien Dumont (Institut Jacques-Monod, FR)
Daniele Fachinetti (Institut Curie, FR)
Gwenaële Guigon (Institut Curie, FR)
Sponsors:
Institut Curie
EMBO
Cytoskeleton
LabEx DEEP
LabEx CelTisPhyBio
Current Opinion in Cell Biology
Gataca Systems
Lumicks
Journal of Cell Science
SBCF
