Research Engineer in Chemical Biology and Cancer Cell Biology

Targeting OSBP, a central protein for cholesterol homeostasis, by natural compounds in pathological contexts

Membrane contact sites enable fast and selective exchange of metabolites between intracellular organelles. We study Oxysterol-Binding Protein (OSBP), which transfers cholesterol from the endoplasmic reticulum to the Golgi apparatus1. Some secondary plant metabolites (Schweinfurthins / Orphilins) bind OSBP, inhibit its lipid exchange activity, and cause a growth arrest of a specific set of cancer cells. Therefore, OSBP is a new candidate for targeting some transformed cells.

Our teams at the Institut de Chimie des Substances Naturelles (Fanny Roussi, CNRS, Gif-sur-Yvette) and at the Institut the Pharmacologie Moléculaire et Cellulaire (Bruno Antonny, Université Côte d’Azur, CNRS, Valbonne) are starting a joint project on OSBP and Schweinfurtins with two aims: understanding the role of OSBP in cell metabolism; unraveling the mechanism of Schweinfurthin action in different cellular contexts, including cancer cells. Ultimately, this project should lead to the development of new anticancer drugs against a specific target. For this, we are seeking a research engineer with expertise and interest in cell biology and chemical biology. The fellow will be a SATT (Société d’Accélération du Transfert de Technologies)-Paris Saclay employee and will thus benefit from this environment and Networking. The candidate should then be in position to apply for post-doctoral fellowships in cancer biology.

The Institut de Chimie des Substances Naturelles (ICSN) is located at Gif-sur-Yvette, close

to Paris, in one of the largest CNRS campus. The ICSN has an outstanding history in the field of chemical biology. The first molecule from the Schweinfurthin series was discovered there. http://www.icsn.cnrs-gif.fr/

The Institut de Pharmacology Moléculaire et Cellulaire (IPMC) is a joint unit between the Université Côte d’Azur and the CNRS. It is located in Sophia Antipolis, the largest high-tech area in Europe, about 20 km from Nice. The molecular basis of OSBP functioning was elucidated there (1). https://www.ipmc.cnrs.fr/cgi-bin/ipmcx.cgi

You will have a relevant PhD, including experience in cell biology or chemical biology, with very strong scientific interest and motivation.

Starting date Sep to Dec 2017

Please submit your CV, a cover letter and the names and contact information of three referees in one PDF document to

• Dr Bruno Antonny at IPMC (antonny@ipmc.cnrs.fr)

• Dr Fanny Roussi at ICSN (fanny.roussi@cnrs.fr)

(1).Mesmin, B. et al. A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP. Cell 155, 830–843 (2013).

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