A 2-year postdoc position is available in the team of Francois Fagotto to participate to a new project on intercellular migration, i.e. the property of cells to migrate within a tissue, thus allowing its dynamic remodelling. The project will focus on the regulation of the actin cytoskeleton and of cadherin-mediated cell adhesion during Xenopus gastrulation.
The Fagotto group has a long-standing interest in studying the cellular basis of morphogenesis using the Xenopus embryo as model system. Our experimental system uniquely combines the possibility of rapid manipulation of gene function, isolation of cells from specific tissues and their analysis with a range of state-of-the-art cell biological and biophysical techniques (high resolution live microscopy, adhesion assays, measurement of cellular forces,…). Furthermore, experimental data are complemented with computer simulation (Nature Communication, in press).
The candidate is expected to have a strong background in cell biology and demonstrated achievement through a solid publication record. Experience with Xenopus embryos would be a plus, but not a requirement. However, excellent experimental skills will be essential since the project relies on microdissections/micromanipulations.