A 3-year postdoctoral position is available in the group of Dr Emmanuel Derivery at the MRC Laboratory of Molecular Biology in Cambridge, UK. Our lab investigates the asymmetric segregation of cell fate determinants during asymmetric division in the context of stem cells. Our approach is highly multidisciplinary, combining in vitro reconstitution of cytoskeleton systems with high-resolution quantitative imaging of cytoskeleton and endosome dynamics during Drosophila development, and also of physical modelling to bridge these different scales.

This project aims to understand the molecular mechanisms of symmetry breaking of the central spindle during asymmetric cell division. The successful applicant will use the broad range of techniques available in the lab, in particular a novel assay based on nanobodies and optogenetics to remodel the cytoskeleton in space and time in vivo.

The MRC Laboratory of Molecular Biology is one of the birthplaces of molecular biology and excels at deciphering the molecular mechanisms of life. It provides an unsurpassed environment for both new and established researchers. Scientists are drawn to the LMB from all over the world, creating a lively and international community for the exchange of ideas and technical innovation. In addition, the LMB has outstanding core facilities, including world-class Electron and Light microscopy facilities harboring in particular two Titan Krios electron microscopes and various super-resolution and light sheet instruments.