Nanotechnology has quickly swept across the medical field by proposing sometimes unprecedented solutions at the furthest limits of current treatments, thereby becoming central to diagnosis and therapy, notably for the regeneration of tissue. A current challenge for regenerative medicine is to create a cohesive and organized cellular assembly without using an external supporting matrix. This is a particularly substantial challenge when it involves synthesizing thick and/or large-sized tissue, or when these tissues must be stimulated like their in vivo counterparts in order to improve their functionality. Another transversal challenge for the tissue engineering field is to develop and mechanically probe model tissues to advance the knowledge of tissue biophysics and mechanics. We have developed a series of magnetic tools to tackle these challenges.
In the present project, we will first explore the role of the extracellular matrix in tissue mechanics thanks to an unprecedented in situ magnetic tissue rheometer. We will develop further a magnetic tissue stretcher to generate engineered tissues presenting cellular anisotropic alignment and we will map the intra-tissular local forces during stretching. Moreover we will identify the best magnetic nanomaterials to provide a high but safe intracellular magnetic load by preventing nanobiodegradation.
Qualified candidates should have a PhD in biophysics and bioengineering or biomechanics with a solid background in cell culture and microscopy. Any knowledge in nanomedical technologies or nanomedicine is also welcome. Excellent level of written english is required. For application, please contact: Claire Wilhelm (claire.wilhelm@univ-paris-diderot.fr) and Myriam Reffay (myriam.reffay@univ-paris-diderot.fr).
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