The main objective of the Ciliate Molecular Biology Meeting 2023 is to bring together international established, junior and developing researchers that use different ciliate biological models to approach biological questions and applications. The meeting will provide a stimulating, diverse and multidisciplinary program, and a forum for open discussions of exciting advances and future directions. Topics will cover both well-established and ground-breaking work, including chromatin modifications/remodeling, epigenetic inheritance, programmed DNA rearrangements, non-coding RNAs, genome evolution, membrane biology and signaling, cilia/cytoskeleton dynamics and morphogenesis/development. Related disciplines being explored in increasing detail with molecular and genomic approaches, namely the biodiversity and ecology of ciliates, and their bacterial symbionts will also be included. To draw students into scientific careers and showcase ciliates as extraordinary biological models, a session dedicated to using ciliates in undergraduate research and classroom laboratories will also take place.